BUSPIRONE AND 1-(2-PYRIMIDINYL)-PIPERAZINE ATTENUATE XYLAZINE-INDUCED ANTINOCICEPTION IN THE MOUSE

被引：0
|
作者：
CAO, BJ
LI, WP
机构：
[1] Department of Pharmacology, Hunan Institute of Pharmaceutical Industry, Changsha
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 11期
关键词：
D O I：
10.1111/j.2042-7158.1994.tb05720.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of subcutaneous pretreatment with buspirone and its major metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) on the antinociceptive effect of xylazine were examined using the mouse acetic acid assay. Both buspirone and 1-PP dose-dependently attenuated the antinociceptive action of subcutaneously administered xylazine (0.8 mg kg(-1)), with ED50 values of 7.3 mg kg(-1) for buspirone and 3.4 mg kg(-1) for 1-PP. Pretreatment with either buspirone (8 mg kg(-1))or 1-PP (4 mg kg(-1)) increased the antinociceptive ED50 of xylazine 3-4-fold. These data support the involvement of alpha(2)-adrenoceptor and 1-PP in the pharmacological activity of buspirone.
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页码：931 / 932
页数：2
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