EFFECTS OF DIABETES ON SPONTANEOUS LOCOMOTOR-ACTIVITY IN MICE

被引：24
|
作者：
KAMEI, J [1 ]
SAITOH, A [1 ]
IWAMOTO, Y [1 ]
FUNADA, M [1 ]
SUZUKI, T [1 ]
MISAWA, M [1 ]
NAGASE, H [1 ]
KASUYA, Y [1 ]
机构：
[1] TORAY INDUSTRIES LTD,BASIC RES LABS,KAMAKURA,KANAGAWA 248,JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 178卷 / 01期
关键词：
LOCOMOTOR ACTIVITY; DIABETES DOPAMINE MESOLIMBIC; DELTA-OPIOID RECEPTOR; MOUSE;
D O I：
10.1016/0304-3940(94)90292-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Spontaneous locomotor activity in diabetic mice as significantly greater than that in non-diabetic mice. Haloperidol and SCH23390, a selective dopamine D-1-receptor antagonist, significantly reduced spontaneous locomotor activity in diabetic mice, but not in non-diabetic mice. Spontaneous locomotor activity in diabetic mice was also reduced by pretreatment with naltrindole, a selective delta-opioid receptor antagonist, and 7-benzylidenenaltrexone, a selective delta(1)-opioid receptor antagonist. The rate of dopamine turnover in the limbic forebrain in diabetic mice was significantly higher than that in non-diabetic mice. These finding suggest that the enhanced spontaneous locomotor activity in diabetic mice may result from increased dopamine neurotransmission, which might be due to an increase in dopamine release in mesolimbic dopamine systems. The increased dopamine neurotransmission in diabetic mice may also be due to the up-regulation of delta-opioid receptor-mediated functions.
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页码：69 / 72
页数：4
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