NICKEL-CATALYZED CONJUGATE ADDITION OF TRIMETHYLALUMINUM TO STERICALLY HINDERED ALPHA,BETA-UNSATURATED KETONES

被引：0
|
作者：
FLEMMING, S
KABBARA, J
NICKISCH, K
NEH, H
WESTERMANN, J
机构：
来源：
SYNTHESIS-STUTTGART | 1995年 / 03期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nickel acetylacetonate is an efficient catalyst for the 1,4-addition of trimethylaluminum to alpha,beta-unsaturated ketones. The reaction is strongly solvent dependent and gives best results in tetrahydrofuran or ethyl acetate. The reaction is especially useful for the nucleophilic 1,4-methyl transfer to sterically hindered enones. A beta-cuparenone synthesis via conjugate methyl group addition to an enone precursor is described.
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页码：317 / 320
页数：4
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