A PROTEIN RELATED TO A PROTEASOMAL SUBUNIT BINDS TO THE INTRACELLULAR DOMAIN OF THE P55 TNF RECEPTOR UPSTREAM TO ITS DEATH DOMAIN

被引：60
|
作者：
BOLDIN, MP [1 ]
METT, IL [1 ]
WALLACH, D [1 ]
机构：
[1] WEIZMANN INST SCI,DEPT MEMBRANE RES & BIOPHYS,IL-76100 REHOVOT,ISRAEL
来源：
FEBS LETTERS | 1995年 / 367卷 / 01期
关键词：
DEATH DOMAIN; RECEPTOR; PROTEASOME; SIGNALING; TUMOR NECROSIS FACTOR; 2-HYBRID SYSTEM;
D O I：
10.1016/0014-5793(95)00534-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel protein that binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor was cloned by two-hybrid screening of a HeLa cell cDNA library. Data bank searches revealed high sequence similarity of the protein (55.11) to yeast, nematode and plant proteins, whose functions are yet unknown. Significant similarity was also found between 55.11 and SEN3, the yeast equivalent of the p112 subunit of the 26S proteasome. Deletion analysis showed that the protein binds to the p55 receptor upstream to the region involved in induction of cell death.
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收藏
页码：39 / 44
页数：6
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