SYNTHESIS OF MONOEPOXIDES OF ARACHIDONIC, EICOSAPENTAENOIC AND DOCOSAHEXAENOIC ACIDS

被引：0
|
作者：
KUKLEV, DV
RYBIN, VG
IMBS, AB
BEZUGLOV, VV
机构：
[1] RUSSIAN ACAD SCI,INST MARINE BIOL,VLADIVOSTOK,RUSSIA
[2] YA OVCHINNIKOV BIOORGAN CHEM INST,MOSCOW,RUSSIA
来源：
BIOORGANICHESKAYA KHIMIYA | 1993年 / 19卷 / 11期
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摘要：
A practical synthesis of cis-monoepoxides from free arachidonic 20 : 4 (n - 6), eicosapentaenoic 20: 5 (n - 3) and docosahexaenoic 22 : 6 (n - 3) acids, their Cytochrome P-450 epoxygenase metabolites, is described. The free polyunsaturated fatty acids (PUFA) were oxidized each by 1.25 eq. m-chloroperbenzoic acid in ethanol to give a mixture of PUFAs' mono-epoxy derivatives (45%) which was separated by HPLC and the individual isomers were characterised by mass spectrometry. All regioisomers of the free PUFAs' cis-monoepoxides were thus obtained.
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页码：1122 / 1127
页数：6
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