STRUCTURE-ACTIVITY RELATIONSHIP OF N6-SUBSTITUTED ADENOSINE DERIVATIVES - AFFINITY FOR ADENOSINE-A1-RECEPTORS AND CARDIOVASCULAR ACTIVITY

被引:0
|
作者
YANG, PC [1 ]
HANSON, G [1 ]
WALSH, GM [1 ]
机构
[1] GD SEARLE & CO, SKOKIE, IL 60077 USA
来源
FASEB JOURNAL | 1991年 / 5卷 / 06期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:A1767 / A1767
页数:1
相关论文
共 50 条
  • [41] N6-SUBSTITUTED ADENOSINE RECEPTOR AGONISTS - POTENTIAL ANTIHYPERTENSIVE AGENTS
    TRIVEDI, BK
    BLANKLEY, CJ
    BRISTOL, JA
    HAMILTON, HW
    PATT, WC
    KRAMER, WJ
    BRUNS, RF
    COHEN, DM
    RYAN, MJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 195 : 32 - MEDI
  • [42] ENZYMATIC DEGRADATION OF N6-SUBSTITUTED ADENOSINE ANALOGUES .1. IN-VITRO STUDY OF ADENOSINE AMINOHYDROLASE ACTION
    TERRINE, C
    SADORGE, P
    GAWER, M
    GUERN, J
    PHYSIOLOGIE VEGETALE, 1969, 7 (04): : 425 - &
  • [43] N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists
    Elzein, Elfatih
    Kalla, Rao
    Li, Xiaofen
    Perry, Thao
    Marquart, Tim
    Micklatcher, Mark
    Li, Yuan
    Wu, Yuzhi
    Zeng, Dewan
    Zablocki, Jeff
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (01) : 161 - 166
  • [44] N6-SUBSTITUTED ADENOSINE RECEPTOR AGONISTS - POTENTIAL ANTIHYPERTENSIVE AGENTS
    TRIVEDI, BK
    BLANKLEY, CJ
    BRISTOL, JA
    HAMILTON, HW
    PATT, WC
    KRAMER, WJ
    JOHNSON, SA
    BRUNS, RF
    COHEN, DM
    RYAN, MJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) : 1043 - 1049
  • [45] 2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors
    Gao, ZG
    Mamedova, LK
    Chen, PR
    Jacobson, KA
    BIOCHEMICAL PHARMACOLOGY, 2004, 68 (10) : 1985 - 1993
  • [46] N-0861 SELECTIVELY ANTAGONIZES ADENOSINE-A1-RECEPTORS INVIVO
    BARRETT, RJ
    DROPPLEMAN, DA
    WRIGHT, KF
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 216 (01) : 9 - 16
  • [47] Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors
    Gomtsyan, A
    Didomenico, S
    Lee, CH
    Matulenko, MA
    Kim, K
    Kowaluk, EA
    Wismer, CT
    Mikusa, J
    Yu, HX
    Kohlhaas, K
    Jarvis, MF
    Bhagwat, SS
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (17) : 3639 - 3648
  • [48] Novel N6-substituted adenosine 5′-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury
    Tracey, WR
    Magee, WP
    Oleynek, JJ
    Hill, RJ
    Smith, AH
    Flynn, DM
    Knight, DR
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (06): : H2780 - H2787
  • [49] Structure-activity relationships of adenosine deaminase inhibitors
    Vittori, S
    Camaioni, E
    Costanzi, S
    Volpini, R
    Lupidi, G
    Cristalli, G
    NUCLEOSIDES & NUCLEOTIDES, 1999, 18 (4-5): : 741 - 742
  • [50] STRUCTURE-ACTIVITY RELATIONSHIPS IN ADENOSINE DEAMINASE INHIBITORS
    SCHAEFFE.HJ
    JOHNSON, RN
    ODIN, E
    HANSCH, C
    JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (03) : 452 - &