Luminol-K3Fe(CN)(6) chemiluminescence system for the determination of glipizide

A rapid and sensitive flow-injection chemiluminescence (CL) method for the determination of glipizide was developed on the basis of finding that glipizide can enhance the CL intensity of the luminol-K3Fe(CN)(6) system. In optimum condition, the increased CL intensity was directly proportional to the concentration of glipizide in the range from 4.0 x 10 (8) g/mL to 1.0 x 10 (6) g/ mL and the detection limit was 1.0 x 10 (-8) g/mL glipizide. The relative standard deviation (RSD) of the developed method was 2.1% with 11 repeated measurements of 1.0 x 10(-7) g/mL glipizide. The developed method has been successfully applied to the analysis of glipizide in its pharmaceutical preparations. (C) 2013 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.