Blast physics and central nervous system injury

被引：27

作者：

Moore, David F. ^{[1
]}

Radovitzky, Raul A. ^{[2
]}

Shupenko, Leslie ^{[1
]}

Klinoff, Andrew ^{[3
]}

Jaffee, Michael S. ^{[1
]}

Rosen, Joseph M. ^{[4
]}

机构：

[1] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Bldg 1,Room B207,6900 Georgia Ave NW, Washington, DC 20309 USA

[2] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA

[3] Raytheon Integrated Def Syst, Dept Adv Algorithms, Woburn, MA 01801 USA

[4] Dartmouth Hitchcock Med Ctr, Dept Plast Surg, Dept Plast Surg, Hanover, NH 03756 USA

来源：

FUTURE NEUROLOGY | 2008年 / 3卷 / 03期

关键词：

Blast overpressure; Blast underpressure; CNS injury; Concussion; High strain rate; Material properties; Neuroprotection; Traumatic brain injury;

D O I：

10.2217/14796708.3.3.243

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of blast on biological tissue is well documented for particular organ systems such as the lung. This is not the case for the CNS, where the mechanism of CNS injury following a detonation and blast wave is unclear. The effect of blast on traumatic brain injury (TBI) has come into particular focus with the Global War on Terror and Operation Iraqi Freedom, and Operation Enduring Freedom where TBI has become known as the signature injury of these conflicts. The reason for the prominence of TBI in these particular conflicts as opposed to others is unclear, but may result from the increased survivability of blast due to improvements in body armor. In this review, we trace the historical context of blast injury and develop current concepts from this framework, in addition to highlighting many remaining unsolved questions.

引用

页码：243 / 250

页数：8

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