The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas

被引：3
|
作者：
El Habr, Elias A. [1 ]
Adamopoulos, Christos [2 ]
Levidou, Georgia [1 ]
Saetta, Aggeliki A. [1 ]
Korkolopoulou, Penelope [1 ]
Piperi, Christina [2 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Pathol 1, Athens 11527, Greece
[2] Natl & Kapodistrian Univ Athens, Sch Med, Dept Biol Chem, Athens 11527, Greece
来源：
NEUROLOGY RESEARCH INTERNATIONAL | 2012年 / 2012卷
关键词：
D O I：
10.1155/2012/454957
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are "endowed" with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors.
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页数：13
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