CYSTIC-FIBROSIS .2. NEW DEVELOPMENTS IN CYSTIC-FIBROSIS - IMPLICATIONS FOR CARRIER DETECTION AND GENETIC-COUNSELING

Cystic fibrosis (CF) is an autosomal recessive disorder found predominantly in people of European origin. Prenatal diagnosis for this disorder is now possible using the polymerase chain reaction technique to detect the most common CF-causing mutation, DELTA-F508. Case studies of prenatal diagnosis and carrier detection are presented and some of the genetic counselling issues related to these investigations are discussed.