KINETIC-ANALYSIS OF TUBULIN EXCHANGE AT MICROTUBULE ENDS AT LOW VINBLASTINE CONCENTRATIONS

被引：78
|
作者：
JORDAN, MA
WILSON, L
机构：
[1] Department of Biological Sciences, University of California, Santa Barbara
来源：
BIOCHEMISTRY | 1990年 / 29卷 / 11期
关键词：
D O I：
10.1021/bi00463a016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have investigated the effects of vinblastine at micromolar concentrations and below on the dynamics of tubulin exchange at the ends of microtubule-associated-protein-rich bovine brain microtubules. The predominant behavior of these microtubules at polymer-mass steady state under the conditions examined was tubulin flux i.e. © 1990, American Chemical Society. All rights reserved.
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页码：2730 / 2739
页数：10
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