APOBEC3G expression and HIV-1 infection in Burkina Faso

被引:1
|
作者
Compaore, Tegwinde Rebeca [1 ]
Soubeiga, Serge Theophile [1 ]
Ouattara, Abdoul Karim [1 ]
Tchelougou, Damehan [1 ]
Bisseye, Cyrille [1 ]
Bakouan, Didier Romuald [2 ]
Compaore, Issaka [1 ]
Dembele, Augustine [2 ]
Yonli, Albert Theophane [1 ]
Obiri-Yeboah, Dorcas [3 ]
Djigma, Wendkuuni Florencia [1 ]
Simpore, Jacques [1 ]
机构
[1] Univ Ouagadougou, Pietro Annigoni Biomol Res Ctr CERBA LABIOGENE, Ouagadougou, Burkina Faso
[2] Permanent Secretary Aids & Sexually Transmitted D, Ouagadougou, Burkina Faso
[3] Univ Cape Coast, Sch Med Sci, Microbiol Dept, Cape Coast, Ghana
关键词
HIV-1; APOBEC3G mRNA; rs8177832; rs35228531; rs6001417; Burkina Faso;
D O I
10.4081/jphia.2018.907
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects' naive to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.
引用
收藏
页码:159 / 161
页数:3
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