INVOLVEMENT OF CYTOCHROME-P-450 IN CONFERRING CHLOROQUINE RESISTANCE TO THE MALARIAL PARASITE, PLASMODIUM-FALCIPARUM

被引：22
|
作者：
SUROLIA, N [1 ]
KARTHIKEYAN, G [1 ]
PADMANABAN, G [1 ]
机构：
[1] INDIAN INST SCI,CTR GENET ENGN,BANGALORE 560012,KARNATAKA,INDIA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 02期
关键词：
D O I：
10.1006/bbrc.1993.2516
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The higher levels of cytochrone P-450 dependent enzyme activities reported earlier are traced to higher levels of cytochrome P-450 (CYPIIB1/B2 like) messenger RNA in the chloroquine resistant than the sensitive strains. The messenger RNA is also induced by phenobarbitone in the sensitive strain. Pretreatment with phenobarbitone affords partial protection to chloroquine toxicity in the sensitive strain and this is not due to a differential accumulation of the drug. © 1993 Academic Press. All rights reserved.
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页码：562 / 569
页数：8
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