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Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, Dept Gastroenterol & Hepatol, NL-1012 WX Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, Dept Gastroenterol & Hepatol, NL-1012 WX Amsterdam, Netherlands