THE MOLECULAR-WEIGHT OF THERAPEUTIC HYALURONAN (SODIUM HYALURONATE) - HOW SIGNIFICANT IS IT

被引：0
|
作者：
AVIAD, AD [1 ]
HOUPT, JB [1 ]
机构：
[1] UNIV TORONTO,MT SINAI HOSP,RHEUMAT DIS UNIT,TORONTO M5G 1X5,ON,CANADA
来源：
JOURNAL OF RHEUMATOLOGY | 1994年 / 21卷 / 02期
关键词：
HYALURONAN; HYALURONIC ACID; SODIUM HYALURONATE; MOLECULAR WEIGHT; THERAPEUTIC; ARTHRITIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Various molecular weight hyaluronic acid (HA) preparations have been injected into joints for the treatment of human and equine osteoarthritis. A therapeutic advantage has been claimed for commercial products with a molecular weight in the range found in normal synovial fluid (SF), compared to lower molecular weight products. But a correlation between molecular weight and efficacy is not borne out by an analysis of the available literature on clinical results, SF viscosity, HA concentration, HA molecular weight and rate of synthesis in joint disease. It is proposed that the beneficial effect of injected HA in joint disease may be due to pharmacological rather than to physical properties.
引用
收藏
页码：297 / 301
页数：5
相关论文
共 50 条
12345