A BACTERICIDAL MONOCLONAL-ANTIBODY SPECIFIC FOR THE LIPOOLIGOSACCHARIDE OF BORDETELLA-PERTUSSIS REDUCES COLONIZATION OF THE RESPIRATORY-TRACT OF MICE AFTER AEROSOL INFECTION WITH BORDETELLA-PERTUSSIS

被引：34
|
作者：
MOUNTZOUROS, KT
KIMURA, A
COWELL, JL
机构：
来源：
INFECTION AND IMMUNITY | 1992年 / 60卷 / 12期
关键词：
D O I：
10.1128/IAI.60.12.5316-5318.1992
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A mouse immunoglobulin G3 monoclonal antibody specific for the core oligosaccharide moiety of the lipooligosaccharide (LOS) of Bordetella pertussis has been shown to have complement-dependent bactericidal activity. This monoclonal antibody exhibits bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition this monoclonal antibody was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection.
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页码：5316 / 5318
页数：3
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