ANALYSIS OF PROTECTIVE AND NONPROTECTIVE MONOCLONAL-ANTIBODIES SPECIFIC FOR BORDETELLA-PERTUSSIS LIPOOLIGOSACCHARIDE

被引：22
|
作者：
SHAHIN, RD [1 ]
HAMEL, J [1 ]
LEEF, MF [1 ]
BRODEUR, BR [1 ]
机构：
[1] LAB CTR DIS CONTROL, NATL LAB IMMUNOL, OTTAWA K1A 0L2, ON, CANADA
来源：
INFECTION AND IMMUNITY | 1994年 / 62卷 / 02期
关键词：
D O I：
10.1128/IAI.62.2.722-725.1994
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, it has been determined that immunoglobulin G1 (IgG1) and IgG3 monoclonal antibodies directed to the lipooligosaccharide A of Bordetella pertussis were able to protect mice from fatal aerosol infection. No correlation was found between the bactericidal activity in vitro in the presence of complement and the protection in mice, since a bactericidal IgG3 did not elicit protection. In addition, no significant difference in protective capacity was observed with bactericidal and nonbactericidal IgG1 antibodies, indicating that bactericidal activity is not a requirement for protection mediated by certain anti-lipooligosaccharide A antibodies. A reduction in protection in C5-deficient mice was observed, suggesting a significant role for complement in certain host defense mechanisms against B. pertussis infection.
引用
收藏
页码：722 / 725
页数：4
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