GLUTAMATE AND OTHER CSF AMINO-ACIDS IN ALZHEIMERS-DISEASE

被引：0
|
作者：
POMARA, N [1 ]
SINGH, R [1 ]
DEPTULA, D [1 ]
CHOU, JCY [1 ]
SCHWARTZ, MB [1 ]
LEWITT, PA [1 ]
机构：
[1] LAFAYETTE CLIN,DETROIT,MI 48207
来源：
AMERICAN JOURNAL OF PSYCHIATRY | 1992年 / 149卷 / 02期
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D O I：
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中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The authors compared CSF amino acid levels of 10 patients with mild to moderate dementia and probable Alzheimer's disease who had never received antidepressant or neuroleptic medication with those of 10 normal subjects of similar age. The Alzheimer's patients had significantly higher levels of CSF glutamate. This finding was not related to age, sex, or severity of dementia. Elevated CSF glutamate may reflect greater glutamatergic activity early in the course of Alzheimer's disease. The authors speculate that the excitotoxic effects of glutamate may contribute to progressive neuronal loss in Alzheimer's disease.
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页码：251 / 254
页数：4
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