INVESTIGATION OF IN-VITRO ANTHELMINTIC ACTIVITY OF CISSAMPELOS PAREIRA LINN AGAINST PHERETIMA POSTHUMA

The world health organization estimates that a staggering 2 billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Development of anthelmintic resistance and high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants has an alternative source of anthelmintics. In view of this, an attempt has been made to study the anthelmintic activity of whole plant of Cissampelos pareira. The activity was checked by in-vitro anthelmintic model by using earthworm. In this current study, alcoholic and aqueous extract at various concentrations (5, 10, 25, 50, 100 mg/ml) were used and studied for paralysis and death of earthworm. All the extract was found not only to paralyze (Vermifuge) but also to kill the earthworm (vermicide). All the extract have significant activity but aqueous extract (100mg/ml) was found to be more effective to execute the earthworm. From this study it is concluded that Cissampelos pareira have potent anthelmintic activity and can be used in the treatment of helminthiasis.