Screening of microRNAs as possible biomarkers in abdominal aortic aneurysm

被引：0
|
作者：
Plana, E. [1 ,2 ]
Galvez, L. [1 ]
Medina, P. [2 ]
Navarro, S. [2 ]
Miralles, M. [1 ,2 ]
机构：
[1] Hosp Univ & Politecn La Fe, Serv Angiol & Cirugia Vasc, Valencia, Spain
[2] Inst Invest Sanit La Fe, Grp Acreditado Invest Hemostasia Trombosis Arteri, Valencia, Spain
来源：
ANGIOLOGIA | 2018年 / 70卷 / 01期
关键词：
miRs; Aneurysm; Biomarkers;
D O I：
10.1016/j.angio.2017.09.001
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Introduction: MicroRNAs (miRs) are small RNA molecules that are involved in several biological processes. Due to their stability and their presence in biological fluids, several studies over the last few years have focused on the use of miRs as biomarkers of different pathologies. Objective: Selection of a group of miRs candidates to be validated as potential biomarkers ofabdominal aortic aneurysm (AAA). Material and methods: A total of 179 miRs were quantified in 7 patients with AAA and in 7 healthy donors, using predesigned panels based on RT-qPCR technology. Results: A total of 10 miRs, dysregulated in patients, were selected as good candidates for studying them as biomarkers. It has been observed that most of these miRs participate in several biological processes related to the formation and development of AAAs. Conclusion: Additional, as well as validation, studies are needed, but some of these miRs could be non-invasive AAA biomarkers. (c) 2017 SEACV. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：13 / 18
页数：6
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