SYNTHETIC STUDIES ON BRYOSTATINS, POTENT ANTINEOPLASTIC AGENTS - SYNTHESIS OF THE C-17-C-27 FRAGMENT OF C-20 DEOXYBRYOSTATINS

被引：15

作者：

OHMORI, K ^{[1
]}

SUZUKI, T ^{[1
]}

NISHIYAMA, S ^{[1
]}

YAMAMURA, S ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 36期

关键词：

D O I：

10.1016/0040-4039(95)01309-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic process toward the bottom-half portion of C-20 deoxygenated series of bryostatins is described. It is noted that the neighboring group participation consisting of a six-membered ring enabled introduction of an unsaturated bond required for the characteristic alpha,beta-unsaturated ester of the bryostatins.

引用

页码：6515 / 6518

页数：4

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