NEW SYNTHETIC APPROACH TO 8-ALLYLTHEOPHYLLINE

被引：1
|
作者：
RYBAR, A
ALFOLDI, J
SMONDRKOVA, I
机构：
[1] Institute of Chemistry, Slovak Academy of Sciences, Bratislava
来源：
MONATSHEFTE FUR CHEMIE | 1994年 / 125卷 / 05期
关键词：
8-ALLYLTHEOPHYLLINE; 8-(1-PROPENYL)-THEOPHYLLINE; REARRANGEMENT OF THE TERMINAL C=C BOND;
D O I：
10.1007/BF00811849
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of 8-allyltheophylline (8) from 5,6-diamino-1,3-dimethyluracil (1) and 3-butenoic acid by Traube's method via 6-amino-5-93-butenoylamino)-1,3-dimethyluracil (2) failed because an attempted alkaline cyclization of the intermediate 2 afforded (E)-8-(1-propenyl)-theophylline (3) under rearrangement of the terminal C=C bond. Therefore, the cyclodehydratation of 6-(3-butenylamino)-5-nitroso-1,3-dimethyluracil (7), available from 6-chloro-1,3-dimethyluracil (5) via 6-(3-butenylamino) derivative 6 has to bc used for obtaining the required product 8.
引用
收藏
页码：565 / 570
页数：6
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