This theoretical paper provides information on the strengths and weaknesses of both the qualitative, quantitative and mixed methods research approaches and seeks to guide those who wish to engage in the research process. The qualitative research approach is explained and compared with the quantitative approach which allows the novice nephrology nurse researcher to determine which approach will be the most useful in exploring their research question. Three of the most common qualitative research approaches of phenomenology; ethnography and Grounded Theory and their particular features are described, explained and critiqued with examples of contemporary nephrology nursing research studies.