EXD2: A new regulator of mitochondrial translation and potential target for cancer therapy

被引：1
|
作者：
Stracker, Travis H. [1 ]
机构：
[1] BIST, Inst Res Biomed IRB Barcelona, Barcelona, Spain
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 03期
关键词：
EXD2; mitochondria; metabolic reprogramming; metformin; cancer metabolism; translation; glutamine; Biology of malignant cells; Cancer stem cells; Mode of action of anticancer agents; Tumor metabolism;
D O I：
10.1080/23723556.2018.1445943
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In recent work we identified Exonuclease 3'-5' domain-containing protein 2 (EXD2) as an RNase required for efficient mitochondrial translation. Here I describe in brief the cellular phenotypes caused by EXD2 deficiency and make the case that EXD2 inhibitors could be valuable agents for cancer therapy.
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页数：3
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