THEORETICAL-MODELS FOR IONTOPHORETIC DELIVERY

被引:63
|
作者
KASTING, GB
机构
[1] The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH
关键词
IONTOPHORESIS; TRANSDERMAL DRUG DELIVERY; SKIN PENETRATION; PERCUTANEOUS ABSORPTION; ION TRANSPORT; MEMBRANE TRANSPORT; ELECTROOSMOSIS; ELECTROOSMOTIC FLOW;
D O I
10.1016/0169-409X(92)90023-J
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Several mathematical models are presented, each of which offers insights into the factors governing iontophoretic drug delivery. None of the models are sufficiently developed to describe all of the phenomena observed experimentally; in fact, none of them can with certainty be claimed to be the right starting point for describing these phenomena. But each allows testable predictions to be made, and future experiments designed with these predictions in mind will ultimately distinguish the useful approaches from those which are less so. As in other scientific endeavors, the utility of the theories lies in their ability to focus experimental efforts on the right questions, thereby improving the efficiency of the discovery process.
引用
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页码:177 / 199
页数:23
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