The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected human ganglia.
机构:
Univ Glasgow, Inst Virol, Med Res Council Virol Unit, Glasgow G11 5JR, Lanark, ScotlandUniv Glasgow, Inst Virol, Med Res Council Virol Unit, Glasgow G11 5JR, Lanark, Scotland