GLYCYLCYCLINES .1. A NEW-GENERATION OF POTENT ANTIBACTERIAL AGENTS THROUGH MODIFICATION OF 9-AMINOTETRACYCLINES

被引：93

作者：

SUM, PE

LEE, VJ

TESTA, RT

HLAVKA, JJ

ELLESTAD, GA

BLOOM, JD

GLUZMAN, Y

TALLY, FP

机构：

[1] American Cyanamid Company, Medical Research Division, New York 10965, Pearl River

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 01期

关键词：

D O I：

10.1021/jm00027a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This report describes the discovery of a new generation of tetracycline antibacterial agents, the ''glycylcyclines''. These agents are notable for their activity against a broad spectrum of tetracycline-susceptible and -resistant Gram-negative and Gram-positive aerobic and anaerobic bacteria possessing various classes of tetracycline-resistant determinants [tet B (efflux), tet M (ribosomal protection)]. The design and synthesis of a number of 7-substituted 9-substituted-amido 6-demethyl-6-deoxytetracyclines are described.

引用

页码：184 / 188

页数：5

共 34 条

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