DIVERGENT EFFECTS OF PHORBOL ESTERS AND INSULIN ON INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 (IGFBP-1) PRODUCTION AND MESSENGER-RNA IN RAT H4IIE HEPATOMA-CELLS

被引：16
|
作者：
UNTERMAN, TG
LACSON, RG
JENTEL, JJ
OEHLER, DT
机构：
[1] VET ADM W SIDE MED CTR,CHICAGO,IL 60612
[2] UNIV ILLINOIS,COLL MED,MED RES SERV,CHICAGO,IL 60612
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 01期
关键词：
D O I：
10.1016/S0006-291X(05)80139-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
125I-IGF-I binding assay, western ligand and immunoblotting, and northern analysis of total RNA reveal that phorbol ester agonists of protein kinase C rapidly enhance IGFBP-1 production and increase the abundance of IGFBP-1 mRNA in rat H4IIE hepatoma cells. In combination with insulin, a potent inhibitor of IGFBP-1 gene transcription, this early effect of phorbol esters is dominant. These results demonstrate divergent regulation of IGFBP-1 by phorbol esters and insulin and indicate that protein kinase C may play a critical role in the regulation of IGFBP-1 and modulation IGF bioactivity in metabolic disease. © 1992 Academic Press, Inc.
引用
收藏
页码：262 / 268
页数：7
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