AGING AND MONOAMINE TURNOVER IN THE LATERAL GENICULATE-NUCLEUS AND VISUAL-CORTEX OF THE RAT

被引：11
|
作者：
HERRERA, AJ [1 ]
MACHADO, A [1 ]
CANO, J [1 ]
机构：
[1] UNIV SEVILLA,FAC FARM,DEPT BIOQUIM BROMATOL & TOXICOL,C PROF GARCIA GONZALEZ S-N,E-41012 SEVILLE,SPAIN
来源：
NEUROCHEMISTRY INTERNATIONAL | 1993年 / 22卷 / 06期
关键词：
D O I：
10.1016/0197-0186(93)90027-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of ageing on the turnover of dopamine, noradrenaline and serotonin in the lateral geniculate nucleus and the visual cortex were evaluated, using high performance liquid chromatography (HPLC) with electrochemical detection. Compared to adult animals, aged rats showed more changes in the visual cortex than in the lateral geniculate nucleus, with dopamine turnover decreased in both structures and noradrenaline turnover unaltered. Changes in serotonin turnover were witnessed only in the visual cortex. A decrease in the monoamine oxidase-A to -B ratio was also observed with increased age for both the lateral geniculate nucleus and visual cortex.
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页码：531 / 539
页数：9
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