MORPHOLOGICAL TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO CELLS BY AMINOBENZYL ALCOHOLS AND NITROBENZYL ALCOHOLS IS CORRELATED WITH INTERCELLULAR COMMUNICATION

被引：3

作者：

MIKALSEN, SO

机构：

[1] Laboratory for Environmental and Occupational Cancer, Institute for Cancer Research, The Norwegian Radium Hospital

来源：

CANCER LETTERS | 1990年 / 52卷 / 03期

关键词：

aminobenzyl alcohols; intercellular communication; morphological cell transformation; nitrobenzyl alcohols;

D O I：

10.1016/0304-3835(90)90188-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication. © 1990.

引用

页码：203 / 208

页数：6

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