MORPHOLOGICAL TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO CELLS BY AMINOBENZYL ALCOHOLS AND NITROBENZYL ALCOHOLS IS CORRELATED WITH INTERCELLULAR COMMUNICATION

被引：3
|
作者：
MIKALSEN, SO
机构：
[1] Laboratory for Environmental and Occupational Cancer, Institute for Cancer Research, The Norwegian Radium Hospital
来源：
CANCER LETTERS | 1990年 / 52卷 / 03期
关键词：
aminobenzyl alcohols; intercellular communication; morphological cell transformation; nitrobenzyl alcohols;
D O I：
10.1016/0304-3835(90)90188-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication. © 1990.
引用
收藏
页码：203 / 208
页数：6
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