EFFECTS OF COPPER, CADMIUM AND NICKEL ON LIVER AND KIDNEY GLUTATHIONE REDOX CYCLE OF RATS (RATTUS SP)

被引：45
|
作者：
CARTANA, J
ROMEU, A
AROLA, L
机构：
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1992年 / 101卷 / 02期
关键词：
D O I：
10.1016/0742-8413(92)90262-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. Glutathione redox cycle alterations induced by acute treatment of nickel, cadmium and copper, have been investigated in liver and kidney of adult male rats. 2. In liver, nickel treatment decreased GSH and GSSG levels, followed by a significant rebound in GSH content. Copper produced drastic reduction in the GSH/GSSG ratio, while cadmium treatment altered GSSG concentrations. 3. In kidney, the glutathione redox cycle remained unaltered after cadmium or nickel exposure, whereas copper caused similar changes to those observed in liver. 4. Hepatic glucose-6-P dehydrogenase and GSSG-reductase activities decreased after copper or nickel injection. GSH-S-transferase activity was altered in various ways, depending on the organ and the metal.
引用
收藏
页码：209 / 213
页数：5
相关论文
共 50 条
  • [31] Effects of cadmium on liver function in diabetic rats
    Rana, SVS
    Rastogi, N
    TOXICOLOGY AND INDUSTRIAL HEALTH, 1998, 14 (03) : 473 - 477
  • [32] Effect of selenium supplementation on the glutathione redox system in the kidney of mice after chronic cadmium exposures
    Nehru, LB
    Bansal, MP
    JOURNAL OF APPLIED TOXICOLOGY, 1997, 17 (01) : 81 - 84
  • [33] Toxicological effects of the concurrent administration of cadmium and arsenic through the food chain on the liver and kidney of rats
    Ezedom, Theresa
    Asagba, Samuel
    Tonukari, Nyerhovwo J.
    JOURNAL OF BASIC AND APPLIED ZOOLOGY, 2020, 81 (01):
  • [34] Disruption of Redox Homeostasis by Succinylacetone In Liver and Kidney of Adolescent Rats
    Castro, Ediandra Tissot
    Ribeiro, Rafael Teixeira
    Bender, Julia Gabrieli
    Zemniacak, Angela Beatris
    Cunha, Samela
    Leipnitz, Guilhian
    Wajner, Moacir
    Amaral, Alexandre Umpierrez
    FREE RADICAL BIOLOGY AND MEDICINE, 2023, 208 : S35 - S35
  • [35] Liver and kidney function and histology in rats exposed to cadmium and ethanol
    Brzóska, MM
    Moniuszko-Jakoniuk, J
    Pilat-Marcinkiewicz, B
    Sawicki, B
    ALCOHOL AND ALCOHOLISM, 2003, 38 (01): : 2 - 10
  • [36] Toxicological effects of the concurrent administration of cadmium and arsenic through the food chain on the liver and kidney of rats
    Ezedom, Theresa
    Asagba, Samuel
    Tonukari, Nyerhovwo J.
    JOURNAL OF BASIC AND APPLIED ZOOLOGY, 2020, 81
  • [37] Effects of Chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and Metallothionein in Liver and Kidney of Rats
    Zhang, Ding
    Gao, Jianfeng
    Zhang, Kerong
    Liu, Xiaodong
    Li, Jiakui
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2012, 149 (01) : 57 - 63
  • [38] Toxicological effects of the concurrent administration of cadmium and arsenic through the food chain on the liver and kidney of rats
    Theresa Ezedom
    Samuel Asagba
    Nyerhovwo J. Tonukari
    The Journal of Basic and Applied Zoology, 81
  • [39] Effects of Chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and Metallothionein in Liver and Kidney of Rats
    Ding Zhang
    Jianfeng Gao
    Kerong Zhang
    Xiaodong Liu
    Jiakui Li
    Biological Trace Element Research, 2012, 149 : 57 - 63
  • [40] Effects of cadmium and copper on Astasia longa: Metal uptake and glutathione levels
    Irato, P
    Piccinni, E
    ACTA PROTOZOOLOGICA, 1996, 35 (04) : 281 - 285
12345