Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications

被引:8
|
作者
Mathur, Sandeep Kumar [1 ]
Jain, Priyanka [2 ]
Mathur, Prashant [3 ]
机构
[1] SMS Med Coll & Hosp, Dept Endocrinol, Jaipur, Rajasthan, India
[2] Inst Genomics & Integrat Biol, Delhi 110007, India
[3] SMS Med Coll & Hosp, Dept Pharmacol, Jaipur 302004, Rajasthan, India
关键词
D O I
10.1155/2011/587495
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy. Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array. This technique has several potential applications in understanding pathologic adipose tissue. They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression. The microarray evidences of molecular basis of obesity and insulin resistance are presented here. Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome.
引用
收藏
页数:16
相关论文
共 50 条
  • [11] The Role of Adipose Tissue in Insulin Resistance in Women of African Ancestry
    Goedecke, Julia H.
    Levitt, Naomi S.
    Evans, Juliet
    Ellman, Nicole
    Hume, David John
    Kotze, Liske
    Tootla, Mehreen
    Victor, Hendriena
    Keswell, Dheshnie
    JOURNAL OF OBESITY, 2013, 2013
  • [12] Emerging role of adipose tissue hypoxia in obesity and insulin resistance
    Ye, J.
    INTERNATIONAL JOURNAL OF OBESITY, 2009, 33 (01) : 54 - 66
  • [14] The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
    Ruskovska, Tatjana
    Bernlohr, David A.
    BIOMEDICINES, 2023, 11 (09)
  • [15] Hypertension and insulin resistance in adipose tissue
    Usui, Isao
    HYPERTENSION RESEARCH, 2023, 46 (06) : 1478 - 1481
  • [16] Oxygenation of adipose tissue in insulin resistance
    Greenhill, Claire
    NATURE REVIEWS ENDOCRINOLOGY, 2021, 17 (02) : 68 - 68
  • [17] Obesity, adipose tissue and insulin resistance
    Acosta Garcia, Edgar
    ACTA BIOQUIMICA CLINICA LATINOAMERICANA, 2012, 46 (02): : 183 - 194
  • [18] Oxygenation of adipose tissue in insulin resistance
    Claire Greenhill
    Nature Reviews Endocrinology, 2021, 17 : 68 - 68
  • [19] Inflammation and Insulin Resistance in Adipose Tissue
    Sondergaard, Esben
    De Ycaza, Ana E. Espinosa
    Morgan-Bathke, Maria
    Lytle, Kelli
    Delivanis, Danae A.
    Leon, Barbara G. Carranza
    Jensen, Michael D.
    DIABETES, 2020, 69
  • [20] Adipose tissue hypoxia and insulin resistance
    Rasouli, Neda
    JOURNAL OF INVESTIGATIVE MEDICINE, 2016, 64 (04) : 830 - 832