THE ENANTIOMERIC RESOLUTION OF CIPROFIBRATE AND RELATED-COMPOUNDS BY HPLC USING CHIRAL STATIONARY PHASES

被引：6
|
作者：
ANDERSON, NH [1 ]
JOHNSTON, D [1 ]
VOJVODIC, PR [1 ]
机构：
[1] STERLING WINTHROP PHARMACEUT RES DIV,ALNWICK NE66 2JH,NORTHD,ENGLAND
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 07期
关键词：
CIPROFIBRATE; CHIRAL HPLC; CELLULOSE TRIACETATE; CYCLODEXTRIN; ALPHA-1 ACID GLYCOPROTEIN;
D O I：
10.1016/0731-7085(92)80071-T
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The attempted chromatographic resolution of the drug ciprofibrate a range of related compounds, containing the chiral moiety 2.2-dichlorocyclopropylbenzene, using five different chiral stationary phases is described. Aqueous mobile phases were used throughout and the successful separation of nine out of 12 pairs of enantiomers was achieved. Structures remote from the chiral centre were seen to affect chiral recognition.
引用
收藏
页码：501 / 505
页数：5
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