The Mediterranean basin: A population genetic study based on 25 X-chromosome SNPs

被引：0

作者：

Tomas, C. ^{[1
,6
,7
]}

Sanchez, J. J. ^{[1
,2
]}

Barbaro, A. ^{[3
]}

Brandt-Casadevall, C. ^{[4
]}

Hernandez, A. ^{[2
]}

Ben Dhiab, M. ^{[5
]}

Ramon, M. M. ^{[6
,7
]}

Morling, N. ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth Sci, Dept Forens Med, Sect Forens Genet, Copenhagen, Denmark

[2] Delegat Canarias, Inst Nacl Toxicol & Ciencias Forenses, Tenerife, Spain

[3] Studio Indagini Med E Forensi SIMEF, Sez Genet Forense, Reggio Di Calabria, Italy

[4] Inst Univ Med Legale, Lausanne, Switzerland

[5] Hop Farhat Hached, Serv Med Legale, Sousse, Tunisia

[6] Univ Illes Balears, Inst Univ Invest Ciencies Salut, Palma De Mallorca, Spain

[7] Univ Illes Balears, Dept Biol, Lab Genet, Palma De Mallorca, Spain

来源：

FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES | 2008年 / 1卷 / 01期

关键词：

X-chromosome; SNPs; Mediterranean populations; Linkage disequilibrium;

D O I：

10.1016/j.fsigss.2007.08.014

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The X-chromosome has valuable characteristics for population genetic studies. In order to investigate the genetics of the human Mediterranean populations further, we developed a 25 X-chromosome SNP-multiplex typing system. The system was based on PCR multiplex amplification and subsequent multiplex single base extension with the SNaPshot reaction, capillary electrophoresis and multicolor fluorescence detection. We investigated 11 Mediterranean populations with the 25 X-chromosome SNPs. A high overall homogeneity was found among the Mediterranean populations except for Moroccans, who differed genetically from the rest of the populations in the Mediterranean area. This result supports the hypothesis of a low incidence of the south-north genetic interchange at the western shores of the Mediterranean basin. A low genetic distance was found between populations in the Middle East and the western part of the Mediterranean area most likely reflecting the strong effect of the Neolithic wave. A certain level of background linkage disequilibrium among the 25 SNPs on the X-chromosome in Ibiza and Cosenza was observed, possibly as a consequence of their demographic history. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：170 / 172

页数：3

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