IMIPENEM INHIBITS IN-VITRO ACTIVITY OF AMPHOTERICIN-B DIRECTED AGAINST ASPERGILLUS-FUMIGATUS

被引：0

作者：

RATH, PM

HULSEWEDE, JW

ANSORG, R

机构：

来源：

ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES | 1995年 / 283卷 / 01期

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中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A decrease of the susceptibility of Aspergillus fumigatus strains to amphotericin B was found when tested in combination with high concentrations (128-2048 mg/l) of the antibacterial agent imipenem by checkerboard titration and agar diffusion assay. Only bacteriologically active imipenem showed the antagonism. The mechanism of action is unknown. However, imipenem and amphotericin B did not react directly, as shown by checkerboard titration with bacterial strains as well as by HPLC analysis. It is concluded that imipenem medication may influence the efficacy of amphotericin B treatment in aspergillosis.

引用

页码：69 / 78

页数：10

共 50 条

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