ANALYSIS OF MYOCARDIAL EDEMA BY MAGNETIC-RESONANCE-IMAGING EARLY AFTER CORONARY-ARTERY OCCLUSION WITH OR WITHOUT REPERFUSION

被引:178
|
作者
GARCIADORADO, D
OLIVERAS, J
GILI, J
SANZ, E
PEREZVILLA, F
BARRABES, J
CARRERAS, MJ
SOLARES, J
SOLERSOLER, J
机构
[1] Servicio de Cardiología, Hospital General Universitari Vall d'Hebron, 08035 Barcelona, Pg Vall d'Hebron s/n
关键词
MAGNETIC RESONANCE IMAGING; MYOCARDIAL EDEMA; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION;
D O I
10.1093/cvr/27.8.1462
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The aim was to analyse the relationship between magnetic resonance (MR) imaging parameters and myocardial water content early after coronary occlusion with or without reperfusion. Methods: 21 pigs were used. After 78 min of coronary occlusion (n=7) or 48 min of coronary occlusion and 30 min of reperfusion (n=14) the heart was excised. In seven animals in the reperfusion protocol the area at risk was perfused for 5 min with an anoxic buffer, starting 5 min after coronary occlusion. Serial T2 weighted and density weighted images of the heart were obtained from apex to base, by using a 1.5 tesla magnetic resonance imager. Water content was measured in samples from control and at-risk myocardium and relaxation parameters were measured in corresponding areas of the magnetic resonance images. Results: Water content was 399(SEM 2) ml.100 g-1 dry tissue in control myocardium, 427(8) in ischaemic myocardium, and 511(8) in reperfused myocardium (p<0.001). Reperfused myocardium that had received intracoronary infusion contained less water than myocardium that did not: 498(9) v 534(4) ml.100 g-1 (p=0.003). T2 relaxation time and T2 weighted signal intensity in the different sampling sites of magnetic resonance images correlated well with water content in the corresponding myocardial samples (r=0.76 and r=0.83) and with the relative volume of extracellular space, as calculated by quantitative histology (r=0.58 and r=0.59, p<0.001). The increase in T2 weighted signal intensity in the area at risk with respect to control myocardium allowed differentiation between ischaemic and reperfused myocardium [9(8)% v 63(3)% respectively]. The area at risk measured by MR imaging correlated very well with that determined at pathology by the fluorescein method (r=0.92). Conclusions: Magnetic resonance imaging allows evaluation of myocardial oedema associated with acute coronary occlusion and reperfusion, and analysis of its spatial distribution. Changes in myocardial water content occurring early during acute myocardial infarction allow quantification of the area at risk and detection of reperfusion by magnetic resonance imaging.
引用
收藏
页码:1462 / 1469
页数:8
相关论文
共 50 条
  • [41] USEFULNESS OF MAGNETIC-RESONANCE-IMAGING FOR DIAGNOSING AN ANOMALOUS CORONARY-ARTERY COURSING BETWEEN AORTA AND PULMONARY TRUNK
    DOOREY, AJ
    WILLS, JS
    BLASETTO, J
    GOLDENBERG, EM
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1994, 74 (02): : 198 - 199
  • [42] NONINVASIVE EVALUATION OF CORONARY-ARTERY BYPASS GRAFT PATENCY BY SPIN-ECHO MAGNETIC-RESONANCE-IMAGING
    KNOLL, P
    BONATTI, G
    PITSCHEIDER, W
    PSENNER, K
    ERLICHER, A
    ZAMMARCHI, A
    CREPAZ, R
    [J]. ZEITSCHRIFT FUR KARDIOLOGIE, 1994, 83 (06): : 439 - 445
  • [43] IMPROVED MYOCARDIAL RECOVERY WITH DEXAMETHASONE AFTER TEMPORARY CORONARY-ARTERY OCCLUSION
    CORDES, G
    ISSELHARD, W
    MULLER, EW
    WELTE, CP
    CRAMER, B
    YAMAMOTO, M
    [J]. ZEITSCHRIFT FUR KARDIOLOGIE, 1981, 70 (04): : 315 - 315
  • [44] CORONARY-ARTERY ENDOTHELIAL FUNCTION AFTER MYOCARDIAL-ISCHEMIA AND REPERFUSION
    SECCOMBE, JF
    SCHAFF, HV
    [J]. ANNALS OF THORACIC SURGERY, 1995, 60 (03): : 778 - 788
  • [45] APROTININ REDUCES MYOCARDIAL DYSFUNCTION AFTER CORONARY-ARTERY OCCLUSION IN DOGS
    ADAMS, RD
    MCCARTHY, RJ
    TUMAN, KJ
    LI, K
    IVANKOVICH, AD
    [J]. ANESTHESIOLOGY, 1994, 81 (3A) : A635 - A635
  • [46] EFFECT OF ETHYL ADENOSINE ON MYOCARDIAL FLOW AFTER CORONARY-ARTERY OCCLUSION
    HELLMANN, DB
    PITT, B
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1976, 231 (05): : 1495 - 1500
  • [47] EFFECTS OF PROPRANOLOL ON MYOCARDIAL DAMAGE RESULTING FROM CORONARY-ARTERY OCCLUSION FOLLOWED BY REPERFUSION
    MIYAZAWA, K
    FUKUYAMA, H
    KOMATSU, E
    YAMAGUCHI, I
    [J]. AMERICAN HEART JOURNAL, 1986, 111 (03) : 519 - 524
  • [48] EFFECTS OF ALLOPURINOL PRETREATMENT ON MYOCARDIAL ULTRASTRUCTURE AND ARRHYTHMIAS FOLLOWING CORONARY-ARTERY OCCLUSION AND REPERFUSION
    GODIN, DV
    BHIMJI, S
    MCNEILL, JH
    [J]. VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1986, 52 (04) : 327 - 341
  • [49] THE EFFECT OF ACUTE CORONARY-ARTERY OCCLUSION DURING CARDIOPLEGIC ARREST AND REPERFUSION ON MYOCARDIAL PRESERVATION
    ROUSOU, JH
    ENGELMAN, RM
    DOBBS, WA
    MEERAN, MK
    [J]. ANNALS OF THORACIC SURGERY, 1982, 33 (04): : 385 - 390
  • [50] EFFECTS OF LATE CORONARY-ARTERY REPERFUSION AFTER MYOCARDIAL NECROSIS IS COMPLETE
    GEFT, IL
    FISHBEIN, MC
    HASHIDA, J
    NINOMIYA, K
    NISHIZAWA, S
    HAENDCHEN, R
    VENKATESH, N
    RIT, JY
    YANO, J
    GANZ, W
    [J]. AMERICAN HEART JOURNAL, 1984, 107 (04) : 623 - 629