ANTIGENIC CROSS-REACTIVITY BETWEEN BORRELIA-BURGDORFERI, BORRELIA-RECURRENTIS, TREPONEMA-PALLIDUM, AND TREPONEMA-PHAGEDENIS

被引：22
|
作者：
LUTHER, B [1 ]
MOSKOPHIDIS, M [1 ]
机构：
[1] MED ALUNTERSUCHUNGSANSTALT, INST HYG, INFEKT IMMUNOL ABT, MARCKMANNSTR 129A, W-2000 HAMBURG 26, GERMANY
来源：
ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES | 1990年 / 274卷 / 02期
关键词：
D O I：
10.1016/S0934-8840(11)80104-0
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The antigenic cross-reactivity between different Borrelia and Treponema species was determined by the indirect immunofluorescence antibody test and sodium dodecyl sulphatepolyacrylamide gel electrophoresis followed by immunoblotting. The protein profiles of Borrelia burgdorferi, Borrelia recurrentis, Treponema pallidum, and Treponema phagedenis revealed essential differences. Using immunoblotting, rabbit immune sera to B. burgdorferi and B. recurrentis exhibited strong cross-reactivities to heterologous borrelial antigens and, to a lesser extent, to treponemal antigens. Immune sera to T. pallidum and T. phagedenis reacted with heterologous treponemal antigens, but exhibited lesser crossreactivities to borrelial antigens. Five B. burgdorferi and seven T. pallidum major antigens were not cross-reacting with antisera raised against T. pallidum and B. burgdorferi, respectively. However, absorption of the investigated antisera with a T. phagedenis ultrasonicate eliminated cross-reacting borrelial and treponemal antibodies. © 1990, Gustav Fischer Verlag, Stuttgart · New York. All rights reserved.
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页码：214 / 226
页数：13
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