A New Hasubanan Alkaloid from Stephania hernandifolia

被引：6

作者：

Deng, Lu-lu ^{[1
,2
,3
]}

Tang, Li-jia ^{[2
,3
]}

Guan, Huan-yu ^{[2
,3
]}

He, Li ^{[2
,3
]}

Zhang, Jian-xin ^{[2
,3
]}

Liu, Jian-hua ^{[2
,3
]}

Hao, Xiao-jiang ^{[2
,3
]}

Zhang, Yuan-hu ^{[2
,3
]}

机构：

[1] Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang 550001, Guizhou, Peoples R China

[2] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China

[3] Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China

来源：

CHINESE HERBAL MEDICINES | 2014年 / 6卷 / 01期

关键词：

cytotoxicity; hasubanan alkaloid; hernsubanine D; Menispermaceae; Stephania hernandifolia;

D O I：

10.1016/S1674-6384(14)60010-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato-graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS, 1D-NMR and 2D-NMR spectral analyses. Results A hasubanan alkaloid, hernsubanine D (1) was isolated from the whole plants of S. hernandifolia. The compound was screened for the cytotoxic activity against two human cancer cell lines in vitro. Conclusion Compound 1 is a new compound without cytotoxicity against A549 and K562 cells.

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页码：70 / 72

页数：3

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