A New Hasubanan Alkaloid from Stephania hernandifolia

被引：6
|
作者：
Deng, Lu-lu [1 ,2 ,3 ]
Tang, Li-jia [2 ,3 ]
Guan, Huan-yu [2 ,3 ]
He, Li [2 ,3 ]
Zhang, Jian-xin [2 ,3 ]
Liu, Jian-hua [2 ,3 ]
Hao, Xiao-jiang [2 ,3 ]
Zhang, Yuan-hu [2 ,3 ]
机构：
[1] Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang 550001, Guizhou, Peoples R China
[2] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China
[3] Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China
来源：
CHINESE HERBAL MEDICINES | 2014年 / 6卷 / 01期
关键词：
cytotoxicity; hasubanan alkaloid; hernsubanine D; Menispermaceae; Stephania hernandifolia;
D O I：
10.1016/S1674-6384(14)60010-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato-graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS, 1D-NMR and 2D-NMR spectral analyses. Results A hasubanan alkaloid, hernsubanine D (1) was isolated from the whole plants of S. hernandifolia. The compound was screened for the cytotoxic activity against two human cancer cell lines in vitro. Conclusion Compound 1 is a new compound without cytotoxicity against A549 and K562 cells.
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页码：70 / 72
页数：3
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