THE STUDY OF GENETIC-MARKERS OF RUSSIANS AND GERMANS WITHIN THE FRAMEWORK OF A JOINT RUSSIAN GERMAN RESEARCH-PROJECT

Information of the distribution of gene frequencies of some serum proteins and erythrocyte enzymes in four Russian populations and one German population was obtained during a joint population genetic research project of Institute of Clinical Genetics of the Medical Genetic Scientific Center, Russian Academy of Medical Sciences, and the Institute of Forensic Medicine, Medical Academy of Magdeburg. The study of polymorphism at the PLG, AHS, FXIIIB, and ITI loci in populations of Russia was performed for the first time. The following values of gene frequencies were estimated for Germans of Magdeburg: Gc - *1S = 0.6092; *1F = 0.1367; *2 = 0.2541; Tf - *B = 0.0068; *C1 = 0.7654; *C2 = 0.1561; *C3 = 0.0717; PI - *M1 = 0.7096; *M2 = 0.1464; *M3 = 0.1128; *S = 0.0192; *Z = 0.0120; PLG - *A V 0.7116; *B = 0.2853; *V = 0.0031; AHS - 0.6710; *2 = 0.3264; *V = 0.0026; FXIIIB - *1 = 0.7610; *2 = 0.0721; *3 = 0.1651; *V = 0.0018; ITI - *1 = 0.5899; *2 = 0.4065; *V = 0.0036; Hp - *1 = 0.4109; *2 = 0.5891; PGM1 -1A = 0.6463; *2A = 0.1816; *1B = 0.1272; *2B = 0.0449; ACP1 - *A = 0.3427; *B = 0.5972; and *C = 0.0601. The mean frequencies of the same genes for Russians are: Gc - *1S = 0.5889; *1F = 0.1231; *2 = 02880; Tf - *B = 0.0044; *C1 = 0.8242; *C2 = 0.1381; *C3 = 0.0260; *D = 0.0073; PI - *M1 = 0.7460; *M2 = 0.1552; *M3 = 0.0862; *S = 0.0066; *Z = 0.0060; PLG - *A = 0.7239; *B = 0.2719; *V = 0.0042; AHS - *1 = 0.6518; *2 = 0.3431; *V = 0.0051; FXIIIB - *1 = 0.6774; *2 = 0.0879; *3 = 0.2347; ITI - *1 = 0.6257; *2 = 0.3687; *V = 0.0056; Hp - *1 = 0.3186; *2 = 0.6814; PGM1 - *1A = 0.5606; *2A = 0.2631; *1B = 0.1038; *2B = 0.0725; ACP1 - *A = 0.3112; *B = 0.6317; and *C = 0.0571. A comparison of populations of German and Slavic language groups was performed using data on the distribution of the studied polymorphisms in Europe. The Germanic language populations were highly homogeneous in genetic matter. The studied Russian groups showed a higher degree of differentiation both from each other and from the German population cluster. The observed differences reflect the geographical distances between populations. The importance of the subunit systems of the BXIII coagulation factor and alpha-2-HS-glycoprotein in the ethnogeographic differentiation of populations is emphasized.