Influence of cadmium ions on endothelin-1 binding and calcium signaling in rat glioma C6 cells

被引：4
|
作者：
Koschel, K [1 ]
Meissner, NN [1 ]
Tas, PWL [1 ]
机构：
[1] UNIV WURZBURG, INST ANAESTHESIOL, D-97078 WURZBURG, GERMANY
来源：
TOXICOLOGY LETTERS | 1995年 / 81卷 / 2-3期
关键词：
cadmium; endothelin-1; Fura-2; Quin-2; Ca2+-influx; C6 rat glioma cells; rat aorta A10 cells;
D O I：
10.1016/0378-4274(95)03434-X
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Cadmium ions did not influence the binding of endothelin-1 (ET-1) to its receptor on the surface of rat glioma C6 and rat aorta A10 cells. This was studied (a) by the binding of (125)1-ET-1 to intact cells in the absence or presence of cadmium (Cd2+) and (b) by analysis of the receptor/ET-1 complex after crosslinking with disuccinimidyl suberate (DSS) or ethylene glycol-bis-(succinimidyl succinate) (EGS) on SDS PAGE, Using Fura-2 and Quin-2 loaded C6 rat glioma cells, it was shown that Cd2+ ions strongly interfered with the ET-1 induced Ca2+-influx in C6 glioma cells (IC50 similar to 10 mu M).
引用
收藏
页码：189 / 195
页数：7
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