VITAMIN-K 2,3-EPOXIDE REDUCTASE - THE BASIS FOR STEREOSELECTIVITY OF 4-HYDROXYCOUMARIN ANTICOAGULANT ACTIVITY

被引：30
|
作者：
THIJSSEN, HHW
BAARS, LGM
VERVOORTPETERS, HTM
机构：
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1988年 / 95卷 / 03期
关键词：
D O I：
10.1111/j.1476-5381.1988.tb11692.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：675 / 682
页数：8
相关论文
共 50 条
  • [21] STUDIES ON THE MECHANISM OF THE VITAMIN-K-DEPENDENT CARBOXYLATION REACTION - CARBOXYLATION WITHOUT THE CONCURRENT FORMATION OF VITAMIN-K 2,3-EPOXIDE
    DEMETZ, M
    SOUTE, BAM
    HEMKER, HC
    FOKKENS, R
    LUGTENBURG, J
    VERMEER, C
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (10) : 5326 - 5329
  • [22] THE RELATIONSHIP BETWEEN INHIBITION OF VITAMIN-K1 2,3-EPOXIDE REDUCTASE AND REDUCTION OF CLOTTING FACTOR ACTIVITY WITH WARFARIN
    CHOONARA, IA
    MALIA, RG
    HAYNES, BP
    HAY, CR
    CHOLERTON, S
    BRECKENRIDGE, AM
    PRESTON, FE
    PARK, BK
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 25 (01) : 1 - 7
  • [23] Tris(3-hydroxypropyl)phosphine is superior to dithiothreitol for in vitro assessment of vitamin K 2,3-epoxide reductase activity
    Krettler, Christoph
    Bevans, Carville G.
    Reinhart, Christoph
    Watzka, Matthias
    Oldenburg, Johannes
    ANALYTICAL BIOCHEMISTRY, 2015, 474 : 89 - 94
  • [24] DISPOSITION OF VITAMIN-K1 2,3-EPOXIDE IN THE RAT
    PRATT, SK
    WINN, MJ
    PARK, BK
    BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 : P617 - P617
  • [25] 4'-AZIDOWARFARIN ALCOHOL (AWA) - A PHOTOACTIVATABLE INHIBITOR OF RAT HEPATIC VITAMIN-K-2,3-EPOXIDE REDUCTASE (KOR)
    FASCO, MJ
    LAWSON, WB
    ZAIDI, IM
    PREUSCH, PC
    FASEB JOURNAL, 1988, 2 (05): : A1535 - A1535
  • [26] Warfarin resistance is associated with a protein component of the vitamin K 2,3-epoxide reductase enzyme complex in rat liver
    Cain, D
    Hutson, SM
    Wallin, R
    THROMBOSIS AND HAEMOSTASIS, 1998, 80 (01) : 128 - 133
  • [27] Assembly of the warfarin-sensitive vitamin K 2,3-epoxide reductase enzyme complex in the endoplasmic reticulum membrane
    Cain, D
    Hutson, SM
    Wallin, R
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (46) : 29068 - 29075
  • [28] CYCLIC INTERCONVERSION OF VITAMIN-K1 AND VITAMIN-K1 2,3-EPOXIDE IN MAN
    BECHTOLD, H
    TRENK, D
    MEINERTZ, T
    ROWLAND, M
    JAHNCHEN, E
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 16 (06) : 683 - 689
  • [29] VITAMIN-K1 2,3-EPOXIDE AND QUINONE REDUCTION - MECHANISM AND INHIBITION
    PREUSCH, PC
    SMALLEY, DM
    FREE RADICAL RESEARCH COMMUNICATIONS, 1990, 8 (4-6): : 401 - 415
  • [30] IDENTIFICATION OF A WARFARIN-SENSITIVE PROTEIN-COMPONENT IN A 200S RAT-LIVER MICROSOMAL FRACTION CATALYZING VITAMIN-K AND VITAMIN-K 2,3-EPOXIDE REDUCTION
    LEE, JJ
    PRINCIPE, LM
    FASCO, MJ
    BIOCHEMISTRY, 1985, 24 (25) : 7063 - 7070
12345