TOPICAL ULTRAVIOLET LIGHT-ABSORBING CHROMOPHORE PROTECTS AGAINST EXPERIMENTAL PHOTOKERATITIS

被引：3
|
作者：
OLDENBURG, JB
GRITZ, DC
MCDONNELL, PJ
机构：
[1] UNIV SO CALIF,SCH MED,DOHENY EYE INST,1355 SAN PABLO,LOS ANGELES,CA 90033
[2] UNIV SO CALIF,SCH MED,DEPT OPHTHALMOL,LOS ANGELES,CA 90033
来源：
ARCHIVES OF OPHTHALMOLOGY | 1990年 / 108卷 / 08期
关键词：
D O I：
10.1001/archopht.1990.01070100098042
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Ultraviolet radiation may play a causative role in a number of human ocular and dermatologic conditions; reduction of environmental UV light exposure may decrease their incidence. We investigated the effects of two different UV light-absorbing chromophores, octyl methoxycinnamate (Parsol-MCX) and butyl methoxydibenzoylmethane (Parsol-1789) on corneal UV light transmittance, and evaluated topically applied Parsol-MCX for its protective effect against experimental UV light-induced keratitis in New Zealand white rabbits. Both Parsol-1789 (UV-A light absorber) and Parsol-MCX (UV-B light absorber) are well tolerated by New Zealand white rabbit eyes. Pretreatment with a single drop of Parsol-MCX reproducibly protected against UV light-induced keratitis, apparently by absorbing greater than 75% of UV-B (peak wavelength, 308 nm) irradiation. © 1990, American Medical Association. All rights reserved.
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页码：1142 / 1144
页数：3
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