CDNA CLONING, SEQUENCE-ANALYSIS AND TISSUE DISTRIBUTION OF A PRECURSOR FOR VASOACTIVE INTESTINAL CONTRACTOR (VIC)

被引：25
|
作者：
SAIDA, K [1 ]
MITSUI, Y [1 ]
机构：
[1] AGCY IND SCI & TECHNOL, FERMENTAT RES INST, DIV CELL SCI & TECHNOL, 1-1-3 HIGASHI, TSUKUBA, IBARAKI 305, JAPAN
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1089卷 / 03期
关键词：
VASOACTIVE INTESTINAL CONTRACTOR (VIC); CDNA SEQUENCE; PRECURSOR; PROCESSING; ENDOTHELIN; (MOUSE);
D O I：
10.1016/0167-4781(91)90186-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A full-length cDNA encoding preprovasoactive intestinal contractor (PPVIC) has been cloned. From the deduced 160 amino acid PPVIC, the mature VIC is predicted to be produced via a 37 residue intermediate, big VIC. The PPVIC also contains a VIC-like peptide of 16 amino acids structurally related to the amino-terminal residues of VIC and flanked by pairs of dibasic amino acids, putative processing sites. RNA blot hybridization with PPVIC cDNA confirmed the PPVIC gene to be expressed in the small and large intestinal tract in a tissue specific manner.
引用
收藏
页码：404 / 406
页数：3
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