CDNA CLONING, SEQUENCE-ANALYSIS AND TISSUE DISTRIBUTION OF A PRECURSOR FOR VASOACTIVE INTESTINAL CONTRACTOR (VIC)

被引：25
|
作者：
SAIDA, K [1 ]
MITSUI, Y [1 ]
机构：
[1] AGCY IND SCI & TECHNOL, FERMENTAT RES INST, DIV CELL SCI & TECHNOL, 1-1-3 HIGASHI, TSUKUBA, IBARAKI 305, JAPAN
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1089卷 / 03期
关键词：
VASOACTIVE INTESTINAL CONTRACTOR (VIC); CDNA SEQUENCE; PRECURSOR; PROCESSING; ENDOTHELIN; (MOUSE);
D O I：
10.1016/0167-4781(91)90186-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A full-length cDNA encoding preprovasoactive intestinal contractor (PPVIC) has been cloned. From the deduced 160 amino acid PPVIC, the mature VIC is predicted to be produced via a 37 residue intermediate, big VIC. The PPVIC also contains a VIC-like peptide of 16 amino acids structurally related to the amino-terminal residues of VIC and flanked by pairs of dibasic amino acids, putative processing sites. RNA blot hybridization with PPVIC cDNA confirmed the PPVIC gene to be expressed in the small and large intestinal tract in a tissue specific manner.
引用
收藏
页码：404 / 406
页数：3
相关论文
共 50 条
  • [1] CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR HUMAN RENIN PRECURSOR
    IMAI, T
    MIYAZAKI, H
    HIROSE, S
    HORI, H
    HAYASHI, T
    KAGEYAMA, R
    OHKUBO, H
    NAKANISHI, S
    MURAKAMI, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (24): : 7405 - 7409
  • [2] MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF CDNA CODING FOR HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) - PHI-27 PRECURSOR
    OKAMOTO, H
    ITOH, N
    OBATA, K
    [J]. REGULATORY PEPTIDES, 1983, 6 (03) : 320 - 320
  • [3] CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR PRECURSOR OF A CRUSTACEAN HYPERGLYCEMIC HORMONE
    WEIDEMANN, W
    GROMOLL, J
    KELLER, R
    [J]. FEBS LETTERS, 1989, 257 (01) : 31 - 34
  • [4] CLONING AND SEQUENCE-ANALYSIS OF THE CDNA FOR THE RAT ATRIAL NATRIURETIC FACTOR PRECURSOR
    YAMANAKA, M
    GREENBERG, B
    JOHNSON, L
    SEILHAMER, J
    BREWER, M
    FRIEDEMANN, T
    MILLER, J
    ATLAS, S
    LARAGH, J
    LEWICKI, J
    FIDDES, J
    [J]. NATURE, 1984, 309 (5970) : 719 - 722
  • [5] CLONING AND SEQUENCE-ANALYSIS OF THE CDNA-ENCODING A SNAKE NEUROTOXIN PRECURSOR
    TAMIYA, T
    LAMOUROUX, A
    JULIEN, JF
    GRIMA, B
    MALLET, J
    FROMAGEOT, P
    MENEZ, A
    [J]. TOXICON, 1985, 23 (04) : 613 - 613
  • [6] CLONING AND SEQUENCE-ANALYSIS OF THE CDNA-ENCODING A SNAKE NEUROTOXIN PRECURSOR
    TAMIYA, T
    LAMOUROUX, A
    JULIEN, JF
    GRIMA, B
    MALLET, J
    FROMAGEOT, P
    MENEZ, A
    [J]. BIOCHIMIE, 1985, 67 (02) : 185 - 189
  • [7] THE STRUCTURE OF ATRIAL NATRIURETIC FACTOR PRECURSOR BY CLONING AND SEQUENCE-ANALYSIS OF CDNA
    MAKI, M
    TAKAYANAGI, R
    MISONO, KS
    PANDEY, K
    TIBBETTS, C
    INAGAMI, T
    [J]. HYPERTENSION, 1984, 6 (05) : 782 - 782
  • [8] CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR OVINE CORTICOTROPIN-RELEASING FACTOR PRECURSOR
    FURUTANI, Y
    MORIMOTO, Y
    SHIBAHARA, S
    NODA, M
    TAKAHASHI, H
    HIROSE, T
    ASAI, M
    INAYAMA, S
    HAYASHIDA, H
    MIYATA, T
    NUMA, S
    [J]. NATURE, 1983, 301 (5900) : 537 - 540
  • [9] CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR THE CANINE NEUROTENSIN NEUROMEDIN N-PRECURSOR
    DOBNER, PR
    BARBER, DL
    VILLAKOMAROFF, L
    MCKIERNAN, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) : 3516 - 3520
  • [10] CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR RAT CORTICOTROPIN-RELEASING FACTOR PRECURSOR
    JINGAMI, H
    MIZUNO, N
    TAKAHASHI, H
    SHIBAHARA, S
    FURUTANI, Y
    IMURA, H
    NUMA, S
    [J]. FEBS LETTERS, 1985, 191 (01) : 63 - 66
12345