COMPLEX DYSTONIA OF PARKINSONS-DISEASE - CLINICAL-FEATURES AND RELATION TO PLASMA LEVODOPA PROFILE

被引：26

作者：

MCHALE, DM ^{[1
]}

SAGE, JI ^{[1
]}

SONSALLA, PK ^{[1
]}

VITAGLIANO, D ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROL,CN 19,NEW BRUNSWICK,NJ 08903

来源：

CLINICAL NEUROPHARMACOLOGY | 1990年 / 13卷 / 02期

关键词：

Chorea; Dystonia; Parkinson's disease; Plasma levodopa profile;

D O I：

10.1097/00002826-199004000-00005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the clinical characteristics and plasma levodopa (LD) profile of complex, LD-associated dystonia in 33 patients with Parkinson's disease (PD). Generalized, abdominal, respiratory, and myoclonic, but not facial or foot, dystonia could be related to specific phases of the plasma LD cycle. Simultaneous clinical observation and determinations of plasma LD concentrations were often necessary to find the most efficacious dosing schedule for these patients. Maintenance of steady plasma LD concentrations within a dystonia-free window of benefit was the best treatment.

引用

页码：164 / 170

页数：7

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