AMINO-ACID SUBSTITUTION AT THE ADH LOCUS OF DROSOPHILA IS FACILITATED BY SMALL POPULATION-SIZE

被引：77
|
作者：
OHTA, T
机构：
[1] National Institute of Genetics
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 10期
关键词：
NEARLY NEUTRAL THEORY; SYNONYMOUS VS NONSYNONYMOUS SUBSTITUTIONS;
D O I：
10.1073/pnas.90.10.4548
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The number of amino acid replacement substitutions and that of synonymous substitutions are examined by using DNA sequences of the Adh locus of Drosophila. The ratio of replacement to synonymous substitutions is higher in sequence comparisons between species than in polymorphisms within species. The ratio for the between-species comparisons is highest in the Hawaiian group and lowest in the obscura group. These observations suggest that amino acid substitutions are facilitated by small population size. The result is in accord with the nearly neutral theory of molecular evolution.
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页码：4548 / 4551
页数：4
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