THE ROLE OF ACCUMBENS GABA-B RECEPTORS IN THE REGULATION OF RAT BEHAVIOR

被引：0
|
作者：
PLAZNIK, A [1 ]
STEFANSKI, R [1 ]
PALEJKO, W [1 ]
KOSTOWSKI, W [1 ]
机构：
[1] MED ACAD WARSAW,DEPT EXPTL & CLIN PHARMACOL,PL-02097 WARSAW,POLAND
来源：
NEUROSCIENCE RESEARCH COMMUNICATIONS | 1993年 / 12卷 / 01期
关键词：
NUCLEUS ACCUMBENS SEPTI; GABAERGIC MECHANISMS; DELTA-AMINO-N-VALERIC ACID; MICROINJECTIONS; MUSCLE TONE;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The specificity of myorelaxant-like effect of baclofen injected to the nucleus accumbens septi was studied in rats pretreated locally with GABA-B receptor antagonist, delta-amino-n-valeric acid (AVA), in behavioural tests. It was found that local injection of AVA (50 and 100 mug) completely antagonized the influence of intra-accumbens injections of baclofen (2.5 and 5 mug per site). AVA was inactive when given alone in the same dose-range. The present data confirm the myorelaxant-like effect of intra-accumbens injections of baclofen, and suggest the involvement of accumbens GABA-B receptors in the action of muscle relaxant drugs. Our study demonstrates important role of GABAergic innervation of the limbic nucleus in the action of muscle relaxant drug.
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页码：23 / 30
页数：8
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