RELAXANT EFFECT OF FORSKOLIN IN RABBIT DETRUSOR SMOOTH-MUSCLE - ROLE OF CYCLIC-AMP

被引：19
|
作者：
MORITA, T [1 ]
WHEELER, MA [1 ]
WEISS, RM [1 ]
机构：
[1] YALE UNIV, SCH MED, UROL SECT, NEW HAVEN, CT 06510 USA
来源：
JOURNAL OF UROLOGY | 1986年 / 135卷 / 06期
关键词：
D O I：
10.1016/S0022-5347(17)46077-0
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Forskolin caused a concentration dependent relaxation of rabbit detrusor muscle strips. The relaxant effect of forskolin was potentiated by the cyclic AMP sensitive phosphodiesterase inhibitor, Ro20-1274. Pretreatment with the beta-adrenergic antagonist, propranolol, did not inhibit the relaxation of rabbit detrusor induced by forskolin, whereas the relaxation response to forskolin was inhibited in part by the adenylate cyclase inhibitor, SQ22536. Forskolin also increased cyclic AMP levels significantly in rabbit detrusor muscle. These data suggest that detrusor muscle relaxation by forskolin may be mediated by cyclic AMP and that forskolin may activate adenylate cyclase without stimulating beta-adrenergic receptors in detrusor muscle.
引用
收藏
页码：1293 / 1295
页数：3
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